Publications 2019

Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart.

Vidal R, Wagner JUG, Braeuning C, Fischer C, Patrick R, Tombor L, Muhly-Reinholz M, John D, Kliem M, Conrad T, Guimaraes-Camboa N, Harvey R, Dimmeler S, Sauer S. JCI Insight. 2019 Nov 14;4(22). pii: 131092. doi: 10.1172/jci.insight.131092.

The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. Ritter N, Ali T, Kopitchinski N, Schuster P, Beisaw A, Hendrix DA, Schulz MH, Müller-McNicoll M, Dimmeler S, Grote P. Dev Cell. 2019 Sep 9 . doi: 10.1016/j.devcel.2019.07.013. Epub 2019 Aug 15.

Exogenous RNAi mechanisms contribute to transcriptome adaption by phased siRNA clusters in Paramecium. Karunanithi S, Oruganti V, Marker S, Rodriguez-Viana AM, Drews F, Pirritano M, Nordström K, Simon M, Schulz MH. Nucleic Acids Res. 2019 Sep 5 doi:10.1093/nar/gkz553

Cloncal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation. Mas-Peiro S, Hoffmann J, Fichtlscherer S, Dorsheimer L, Rieger MA, Dimmeler S, Vasa-Nicotera M, Zeiher AM. Eur Heart J. 2019 Sep 3. doi: 10.1093/eurheartj/ehz591. [Epub ahead of print]

Automated analysis of small RNA datasets with RAPID. Karunanithi S, Simon M, Schulz MH. PeerJ. 2019 Apr 10. doi:10.7717/peerj.6710. eCollection 2019.

Inhibition of the HIF1α-Induced Cardiospecific HERNA1 eRNA Protects from Heart Disease. Mirtschink P, Bischof C, Pham MD, Sharma R, Khadayate S, Rossi G, Fankhauser N, Traub S, Sossalla S, Hagag E, Berthonneche C, Sarre A, Stehr SN, Grote P, Pedrazzini T, Dimmeler S, Krek W, Krishnan J. Circulation. 2019 Mar 29. doi: 10.1161/CIRCULATIONAHA.118.036769. [Epub ahead of print]

Bone marrow and plasma FGF-23 in heart failure patients: novel insights into the heart-bone axis. von Jeinsen B, Sopova K, Palapies L, Leistner DM, Fichtlscherer S, Seeger FH, Honold J, Dimmeler S, Aßmus B, Zeiher AM, Keller T. ESC Heart Fail. 2019 Mar 25. doi: 10.1002/ehf2.12416. [Epub ahead of print]

Long non-coding RNAs in vascular biology and disease. Jaé N, Heumüller AW, Fouani Y, Dimmeler S. Vascul Pharmacol. 2019 Mar;114:13-22. doi: 10.1016/j.vph.2018.03.003. Review.

Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation. Cremer S, Michalik KM, Fischer A, Pfisterer L, Jaé N, Winter C, Boon RA, Muhly-Reinholz M, John D, Uchida S, Weber C, Poller W, Günther S, Braun T, Li DY, Maegdefessel L, Perisic Matic L, Hedin U, Soehnlein O, Zeiher A, Dimmeler S. Circulation. 2019 Mar 5;139(10):1320-1334. doi: 10.1161/CIRCULATIONAHA.117.029015.

Circular RNA Control of Vascular Smooth Muscle Cell Functions. Heumüller AW, Dimmeler S. Circ Res. 2019 Feb 15;124(4):456-458. doi: 10.1161/CIRCRESAHA.118.314521. 

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm. Kumar S, Boon RA, Maegdefessel L, Dimmeler S, Jo H. Circ Res. 2019 Feb 15;124(4):619-630. doi: 10.1161/CIRCRESAHA.118.312438.

Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review. Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH. J Am Coll Cardiol. 2019 Jan 22;73(2):190-209. doi: 10.1016/j.jacc.2018.09.089. Review.

Identification and regulation of the long non-coding RNA Heat2 in heart failure Boeckel JN, Perret MF, Glaser SF, Seeger T, Heumüller AW, Chen W, John D, Kokot KE, Katus HA, Haas J, Lackner MK, Kayvanpour E, Grabe N, Dieterich C, von Haehling S, Ebner N, Hünecke S, Leuschner F, Fichtlscherer S, Meder B, Zeiher AM, Dimmeler S, Keller T. J Mol Cell Cardiol. 2019 Jan. doi:10.1016/j.yjmcc.2018.11.004. Epub 2018 Nov 13.

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure. Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Ecke A, Abou-El-Ardat K, Schmid T, Brüne B, Wagner S, Serve H, Hoffmann J, Seeger F, Dimmeler S, Zeiher AM, Rieger MA JAMA Cardiol. 2o19 Jan 1. doi: 10.1001/jamacardio.2018.3965

Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling. Hofmann P, Sommer J, Theodorou K, Kirchhof L, Fischer A, Li Y, Perisic L, Hedin U, Maegdefessel L, Dimmeler S, Boon RA. Cardiovasc Res. 2019 Jan 1;115(1):230-242. doi: 10.1093/cvr/cvy206.